产品货号：
Z27687
中文名称：
SRC3/NCOA3抗体
英文名称：
Anti-SRC3/NCOA3 Antibody
产品规格：
100μg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-SRC3/NCOA3 Antibody |
| 指标别名 | ACTR;AIB 1;AIB1;CBP interacting protein;KAT13B;NCoA 3;NCOA3;nuclear receptor coactivator 3;pCIP;SRC 3;SRC3;SRC3/NCOA3;TRAM 1;TRAM1 |
| 克隆性 | Polyclonal |
| 检验物种 | human |
| 应用范围 | ELISA,IHC,WB |
| 基因名称 | NCOA3 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to an internal region of human NCOA3 isoform a protein. |
| 计算分子量 | 155kDa |
| 成分 | 0.02M Potassium Phosphate,0.15M Sodium Chloride,pH7.2,0.01% (w/v) Sodium Azide |
| 纯化方式 | This product was affinity purified from monospecific antiserum by immunoaffinity chromatography.This antibody reacts with several isoforms of human NCOA3 protein (a,b,d,e and f).A BLAST analysis was used to suggest cross-reactivity with NCOA3 from human and macaque sources based on a 100% homology with the immunizing sequence.Expect partial reactivity with NCOA3 from dog,bovine,mouse and rat sources based on partial sequence homology.Cross-reactivity with NCOA3 from other sources has not been determined. |
| 浓度 | 1.24mg/mL by UV absorbance at 280nm |
| 产品形态 | 溶液 |
| 保存条件 | Store vial at -20℃ prior to opening.Aliquot contents and freeze at -20℃ or below for extended storage.Avoid cycles of freezing and thawing.Centrifuge product if not completely clear after standing at room temperature.This product is stable for several weeks at 4℃ as an undiluted liquid.Dilute only prior to immediate use.Expiration date is one (1) year from date of opening. |
| 背景资料 | The NCOA3 (also known as nuclear receptor coactivator 3 isoform a) is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions in a hormone-dependent fashion.The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex.NCOA3 probably acts via remodeling of chromatin and is involved in the coactivation of different nuclear receptors,such as for steroids (GR and ER),retinoids (RARs and RXRs),thyroid hormone (TRs),vitamin D3 (VDR) and prostanoids (PPARs).NCOA3 is also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit.NCOA3 may be associated with diseases such as breast cancer and meningothelial meningioma.Anti-NCOA3 Antibody is useful for researchers interested in cancer research,chromatin binding,transcription coactivator activity,Immunology,and Nuclear Signaling research. |
| Uniprot ID | Q9Y6Q9 |
| 基因名全称 | Nuclear receptor coactivator 3 |
| 推荐稀释比 | ELISA:1:175,000 IHC:5μg/mL IP:1:100 WB:1:500 - 1:1,000 |
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